Stevan Jovetic was tried as a central striker in a 4-2-3-1 but then he got injured so a return to 4-3-3 is possible. Tuttosport about the game;

“The coach will most likely go for a 4-3-3 and play Juan Jesus and Gary Medel as centre backs. Santon and Nagatomo will replace D’Ambrosio (disastrous Saturday on Bonucci’s goal) and Telles (injured) as fullbacks. In midfield Borzovic is sure to start with Melo or Kondogbia (the latter being a more likely starter) while Gnoukouri should start in front of the defense. Should he start that will be his second game as a starter. In attack Perisic, Eder and Ljajic.”

Source: Tuttosport